{"id":9086,"date":"2025-03-28T08:42:26","date_gmt":"2025-03-28T08:42:26","guid":{"rendered":"https:\/\/korcosmetics.vn\/?p=9086"},"modified":"2025-08-15T08:08:16","modified_gmt":"2025-08-15T08:08:16","slug":"tong-hop-nghien-cuu-centella-asiatica-trong-my-pham-phan-tich-toan-dien-ve-thanh-phan-loi-ich-ung-dung-va-quy-dinh","status":"publish","type":"post","link":"https:\/\/korcosmetics.vn\/en\/tong-hop-nghien-cuu-centella-asiatica-trong-my-pham-phan-tich-toan-dien-ve-thanh-phan-loi-ich-ung-dung-va-quy-dinh\/","title":{"rendered":"[T\u1ed5ng h\u1ee3p nghi\u00ean c\u1ee9u] Centella Asiatica trong m\u1ef9 ph\u1ea9m: Ph\u00e2n t\u00edch to\u00e0n di\u1ec7n v\u1ec1 th\u00e0nh ph\u1ea7n, l\u1ee3i \u00edch, \u1ee9ng d\u1ee5ng v\u00e0 quy \u0111\u1ecbnh"},"content":{"rendered":"
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Centella Asiatica (Rau m\u00e1) l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n thi\u00ean nhi\u00ean \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 cao trong ng\u00e0nh m\u1ef9 ph\u1ea9m nh\u1edd kh\u1ea3 n\u0103ng l\u00e0m d\u1ecbu da, ph\u1ee5c h\u1ed3i t\u1ed5n th\u01b0\u01a1ng v\u00e0 ch\u1ed1ng oxy h\u00f3a m\u1ea1nh m\u1ebd. Nh\u01b0ng \u0111i\u1ec1u g\u00ec khi\u1ebfn Centella Asiatica tr\u1edf th\u00e0nh “ng\u00f4i sao” trong c\u00e1c s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c da? B\u00e0i vi\u1ebft n\u00e0y s\u1ebd cung c\u1ea5p c\u00e1i nh\u00ecn to\u00e0n di\u1ec7n<\/strong> v\u1ec1 th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh, c\u00f4ng d\u1ee5ng n\u1ed5i b\u1eadt, \u1ee9ng d\u1ee5ng trong m\u1ef9 ph\u1ea9m c\u0169ng nh\u01b0 nh\u1eefng quy \u0111\u1ecbnh quan tr\u1ecdng li\u00ean quan \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng Centella Asiatica t\u1ea1i Vi\u1ec7t Nam v\u00e0 c\u00e1c th\u1ecb tr\u01b0\u1eddng qu\u1ed1c t\u1ebf. N\u1ebfu b\u1ea1n \u0111ang t\u00ecm ki\u1ebfm m\u1ed9t t\u00e0i li\u1ec7u t\u1ed5ng h\u1ee3p chi ti\u1ebft v\u1ec1 Centella Asiatica trong m\u1ef9 ph\u1ea9m<\/strong>, \u0111\u1eebng b\u1ecf l\u1ee1 b\u00e0i vi\u1ebft c\u1ee7a KOR<\/strong><\/a> nh\u00e9!<\/em><\/p>\n

\"\"<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n

1. Gi\u1edbi thi\u1ec7u v\u1ec1 th\u00e0nh ph\u1ea7n RAU M\u00c1<\/b><\/h2>\n

Centella asiatica (L.) <\/span><\/i>Urb., th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 rau m\u00e1, l\u00e0 m\u1ed9t lo\u1ea1i c\u00e2y th\u00e2n th\u1ea3o thu\u1ed9c h\u1ecd Apiaceae, ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i kh\u1eafp Ch\u00e2u \u00c1 v\u00e0 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn v\u00ec l\u1ecbch s\u1eed s\u1eed d\u1ee5ng l\u00e2u \u0111\u1eddi trong y h\u1ecdc c\u1ed5 truy\u1ec1n.\u00a0<\/span><\/p>\n

Trong nhi\u1ec1u th\u1ebf k\u1ef7, lo\u1ea1i c\u00e2y n\u00e0y \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 cao v\u00ec c\u00e1c \u0111\u1eb7c t\u00ednh tr\u1ecb li\u1ec7u \u0111a d\u1ea1ng c\u1ee7a n\u00f3, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u1ebft th\u01b0\u01a1ng v\u00e0 nhi\u1ec1u b\u1ec7nh ngo\u00e0i da. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, Centella asiatica \u0111\u00e3 thu h\u00fat \u0111\u01b0\u1ee3c s\u1ef1 ch\u00fa \u00fd \u0111\u00e1ng k\u1ec3 trong ng\u00e0nh c\u00f4ng nghi\u1ec7p m\u1ef9 ph\u1ea9m to\u00e0n c\u1ea7u, chuy\u1ec3n t\u1eeb c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa b\u1ec7nh truy\u1ec1n th\u1ed1ng th\u00e0nh m\u1ed9t th\u00e0nh ph\u1ea7n ch\u00ednh trong nhi\u1ec1u c\u00f4ng th\u1ee9c ch\u0103m s\u00f3c da.\u00a0<\/span><\/p>\n

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Gi\u1edbi thi\u1ec7u v\u1ec1 th\u00e0nh ph\u1ea7n RAU M\u00c1<\/figcaption><\/figure>\n

S\u1ef1 gia t\u0103ng ph\u1ed5 bi\u1ebfn n\u00e0y \u0111\u01b0\u1ee3c th\u00fac \u0111\u1ea9y b\u1edfi c\u00e1c b\u1eb1ng ch\u1ee9ng khoa h\u1ecdc ng\u00e0y c\u00e0ng t\u0103ng x\u00e1c nh\u1eadn nhi\u1ec1u l\u1ee3i \u00edch v\u1ec1 da li\u1ec5u c\u1ee7a rau m\u00e1, ph\u00f9 h\u1ee3p v\u1edbi s\u1edf th\u00edch ng\u00e0y c\u00e0ng t\u0103ng c\u1ee7a ng\u01b0\u1eddi ti\u00eau d\u00f9ng \u0111\u1ed1i v\u1edbi c\u00e1c gi\u1ea3i ph\u00e1p ch\u0103m s\u00f3c da t\u1ef1 nhi\u00ean v\u00e0 hi\u1ec7u qu\u1ea3.<\/span><\/p>\n

2. Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u1ee7a Centella Asiatica<\/b><\/h2>\n

Centella asiatica <\/span><\/i>t\u1ef1 h\u00e0o c\u00f3 h\u1ed3 s\u01a1 h\u00f3a th\u1ef1c v\u1eadt phong ph\u00fa v\u00e0 ph\u1ee9c t\u1ea1p, v\u1edbi nhi\u1ec1u th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc g\u00f3p ph\u1ea7n v\u00e0o c\u00e1c ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc \u0111a d\u1ea1ng c\u1ee7a n\u00f3.\u00a0<\/span>Trong s\u1ed1 \u0111\u00f3, saponin, \u0111\u1eb7c bi\u1ec7t l\u00e0 triterpenoid, \u0111\u01b0\u1ee3c coi l\u00e0 h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc ch\u00ednh ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho nhi\u1ec1u l\u1ee3i \u00edch \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u1ee7a c\u00e2y n\u00e0y.\u00a0<\/span><\/p>\n

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Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u1ee7a Centella Asiatica<\/figcaption><\/figure>\n

Asiaticoside, <\/b>m\u1ed9t glycoside triterpene n\u1ed5i b\u1eadt c\u00f3 trong Centella asiatica, \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i v\u1ec1 kh\u1ea3 n\u0103ng k\u00edch th\u00edch t\u1ed5ng h\u1ee3p collagen v\u00e0 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng. Nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng asiaticoside c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng s\u1ea3n xu\u1ea5t collagen lo\u1ea1i I v\u00e0 III, c\u00e1c th\u00e0nh ph\u1ea7n quan tr\u1ecdng c\u1ee7a khung c\u1ea5u tr\u00fac da.<\/span><\/p>\n

Madecassoside<\/b>, m\u1ed9t glycoside triterpene quan tr\u1ecdng kh\u00e1c, c\u0169ng c\u00f3 nhi\u1ec1u trong Centella asiatica v\u00e0 n\u1ed5i ti\u1ebfng v\u1edbi \u0111\u1eb7c t\u00ednh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng, ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng oxy h\u00f3a.\u00a0<\/span><\/p>\n

Axit asiatic, <\/b>m\u1ed9t aglycone triterpene c\u00f3 trong c\u00e2y, th\u1ec3 hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng oxy h\u00f3a. N\u00f3 c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh ti\u1ec1m t\u00e0ng v\u00e0 c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 b\u1ea3o v\u1ec7 da kh\u1ecfi t\u00e1c h\u1ea1i c\u1ee7a tia UV.\u00a0<\/span><\/p>\n

Axit madecassic<\/b>, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 axit centellic, l\u00e0 m\u1ed9t aglycone triterpene quan tr\u1ecdng kh\u00e1c \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong Centella asiatica g\u00f3p ph\u1ea7n k\u00edch th\u00edch collagen.<\/span><\/p>\n

Ngo\u00e0i ra, c\u00f2n c\u00e1c glycoside triterpenoid kh\u00e1c nh\u01b0 <\/span>centelloside, brahmosid v\u00e0 brahminosid<\/b> c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong c\u00e2y<\/span><\/p>\n

\u21d2 S\u1ef1 hi\u1ec7n di\u1ec7n nh\u1ea5t qu\u00e1n c\u1ee7a asiaticoside, madecassoside, axit asiatic v\u00e0 axit madecassic l\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n ch\u00ednh trong nhi\u1ec1u ngu\u1ed3n th\u00f4ng tin khoa h\u1ecdc v\u00e0 s\u1ea3n ph\u1ea9m cho th\u1ea5y vai tr\u00f2 trung t\u00e2m c\u1ee7a ch\u00fang trong c\u00e1c t\u00e1c d\u1ee5ng v\u1ec1 da li\u1ec5u c\u1ee7a Centella asiatica. Do \u0111\u00f3, hi\u1ec7u qu\u1ea3 c\u1ee7a chi\u1ebft xu\u1ea5t Centella asiatica trong m\u1ef9 ph\u1ea9m c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 b\u1edfi n\u1ed3ng \u0111\u1ed9 v\u00e0 t\u01b0\u01a1ng t\u00e1c hi\u1ec7p \u0111\u1ed3ng c\u1ee7a c\u00e1c triterpenoid c\u1ee5 th\u1ec3 n\u00e0y.<\/span><\/p>\n

Ngo\u00e0i saponin, Centella asiatica c\u00f2n ch\u1ee9a m\u1ed9t l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3 flavonoid (3-glucosylquercetin, 3-glucosylkaempferol v\u00e0 7-glucosylkaempferol). C\u00e1c h\u1ee3p ch\u1ea5t polyphenolic n\u00e0y \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i v\u00ec \u0111\u1eb7c t\u00ednh ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ed1ng vi\u00eam m\u1ea1nh m\u1ebd. V\u00e0 \u0111\u00e2y l\u00e0 m\u1ed9t kh\u00eda c\u1ea1nh quan tr\u1ecdng c\u1ee7a \u201cc\u00f4ng t\u00e1c\u201d ch\u1ed1ng l\u00e3o h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 da \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong c\u00e1c \u1ee9ng d\u1ee5ng m\u1ef9 ph\u1ea9m.<\/span><\/p>\n

S\u1ef1 \u0111a d\u1ea1ng phong ph\u00fa c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc n\u00e0y cho th\u1ea5y m\u1ed9t c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng ph\u1ee9c t\u1ea1p v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng hi\u1ec7p \u0111\u1ed3ng \u0111\u1ed1i v\u1edbi chi\u1ebft xu\u1ea5t Centella asiatica. Hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong c\u00e1c \u1ee9ng d\u1ee5ng m\u1ef9 ph\u1ea9m c\u00f3 th\u1ec3 ph\u00e1t sinh t\u1eeb c\u00e1c t\u00e1c \u0111\u1ed9ng k\u1ebft h\u1ee3p c\u1ee7a nhi\u1ec1u h\u1ee3p ch\u1ea5t t\u01b0\u01a1ng t\u00e1c th\u00f4ng qua nhi\u1ec1u con \u0111\u01b0\u1eddng sinh h\u1ecdc kh\u00e1c nhau<\/span><\/p>\n

B\u1ea3ng 1: C\u00e1c th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc ch\u00ednh c\u1ee7a Centella asiatica v\u00e0 c\u00e1c \u0111\u1eb7c t\u00ednh \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o<\/b><\/p>\n

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Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries.<\/em><\/figcaption><\/figure>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
T\u00ean h\u1ee3p ch\u1ea5t<\/b><\/td>\nL\u1edbp h\u00f3a h\u1ecdc<\/b><\/td>\nT\u00ednh ch\u1ea5t\/L\u1ee3i \u00edch \u0111\u00e3 b\u00e1o c\u00e1o<\/b><\/td>\n<\/tr>\n
Asiaticoside<\/b><\/td>\nGlycoside Triterpene<\/span><\/td>\nK\u00edch th\u00edch t\u1ed5ng h\u1ee3p collagen, th\u00fac \u0111\u1ea9y l\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng, ch\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a, c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u0111\u00e0n h\u1ed3i c\u1ee7a da.<\/span><\/td>\n<\/tr>\n
Madecassoside<\/b><\/td>\nGlycoside Triterpene<\/span><\/td>\nL\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng, ch\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a, d\u01b0\u1ee1ng \u1ea9m cho da, c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 da.<\/span><\/td>\n<\/tr>\n
Asiatic acid<\/b><\/td>\nAglycone Triterpene<\/span><\/td>\nCh\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a, c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh, b\u1ea3o v\u1ec7 da kh\u1ecfi t\u1ed5n th\u01b0\u01a1ng do tia UV.<\/span><\/td>\n<\/tr>\n
Madecassic acid<\/b><\/td>\nAglycone Triterpene<\/span><\/td>\nCh\u1ed1ng vi\u00eam, k\u00edch th\u00edch t\u1ed5ng h\u1ee3p collagen, th\u00fac \u0111\u1ea9y t\u00e1i t\u1ea1o da.<\/span><\/td>\n<\/tr>\n
Flavonoids<\/b><\/td>\nPolyphenol<\/span><\/td>\nCh\u1ed1ng oxy h\u00f3a m\u1ea1nh, ch\u1ed1ng vi\u00eam, b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i t\u00e1c h\u1ea1i c\u1ee7a g\u1ed1c t\u1ef1 do, c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng m\u1ea1ch m\u00e1u.<\/span><\/td>\n<\/tr>\n
Tinh d\u1ea7u (Essential Oils)<\/b><\/td>\nTerpenes<\/span><\/td>\nC\u00f3 h\u01b0\u01a1ng th\u01a1m \u0111\u1eb7c tr\u01b0ng, c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng tr\u1ecb li\u1ec7u (v\u00ed d\u1ee5: kh\u00e1ng khu\u1ea9n).<\/span><\/td>\n<\/tr>\n
Axit amin (Amino Acids)<\/b><\/td>\nH\u1ee3p ch\u1ea5t h\u1eefu c\u01a1<\/span><\/td>\nTh\u00e0nh ph\u1ea7n c\u1ea5u t\u1ea1o protein, gi\u00fap d\u01b0\u1ee1ng \u1ea9m v\u00e0 nu\u00f4i d\u01b0\u1ee1ng l\u00e0n da.<\/span><\/td>\n<\/tr>\n
Axit b\u00e9o (Fatty Acids)<\/b><\/td>\nLipid<\/span><\/td>\nH\u1ed7 tr\u1ee3 ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 da, cung c\u1ea5p \u0111\u1eb7c t\u00ednh l\u00e0m m\u1ec1m da, d\u01b0\u1ee1ng \u1ea9m cho da.<\/span><\/td>\n<\/tr>\n
Sterols<\/b><\/td>\nSteroid<\/span><\/td>\nC\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam v\u00e0 \u0111i\u1ec1u h\u00f2a da.<\/span><\/td>\n<\/tr>\n
Vitamin (A, B, C)<\/b><\/td>\nH\u1ee3p ch\u1ea5t h\u1eefu c\u01a1<\/span><\/td>\n\u0110\u00f3ng g\u00f3p v\u00e0o s\u1ee9c kh\u1ecfe t\u1ed5ng th\u1ec3 c\u1ee7a l\u00e0n da v\u00e0 mang l\u1ea1i l\u1ee3i \u00edch ch\u1ed1ng oxy h\u00f3a.<\/span><\/td>\n<\/tr>\n
Beta-carotene<\/b><\/td>\nCarotenoid<\/span><\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a, ti\u1ec1n ch\u1ea5t c\u1ee7a vitamin A.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

3. L\u1ee3i \u00edch ti\u1ec1m n\u0103ng cho da v\u00e0 \u1ee9ng d\u1ee5ng Rau M\u00e1 trong m\u1ef9 ph\u1ea9m<\/b><\/h2>\n

Rau m\u00e1 (<\/span>Centella asiatica<\/span><\/i>) ch\u1ee9a nhi\u1ec1u h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c saponin triterpenoid nh\u01b0 <\/span>asiaticoside, madecassoside, asiatic acid v\u00e0 madecassic acid<\/b>, gi\u00fap th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o da, k\u00edch th\u00edch t\u1ed5ng h\u1ee3p collagen v\u00e0 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh l\u00e0nh v\u1ebft th\u01b0\u01a1ng.<\/span><\/p>\n